The gang's five-month trial heard that they exploited at least six troubled girls as young as 11 in the English city of Oxford, plying them with drugs before forcing them to perform sex acts.
Brothers Akhtar and Anjum Dogar were handed life terms by a judge at London's Old Bailey court along with Kamar Jamil and brothers Mohammed and Bassam Karrar.
Two more defendants, Assad Hussain and Zeeshan Ahmed, were jailed for seven years each.
Four of the victims, who were abused between 2004 and last year, had lived in state-run children's homes.
The trial heard that the girls, aged between 11 and 15 at the time of the abuse, were repeatedly and violently raped, beaten and in one case forced to have an abortion at the age of 12.
They were sometimes driven across the country to have sex with other men. Several were gang-raped.
The men -- who were all of Pakistani origin except the North African Karrar brothers -- were found guilty last month of a catalogue of crimes including rape, trafficking and organising prostitution.
One girl told a friend that she submitted to the abuse because she just wanted to be loved.
The family of one victim said in a statement on Thursday that the men “took her from us and we will never get those lost years back.”
Police and social services were forced to apologise after missing several chances to catch the gang.
The trial followed the jailing last year of nine Asian men who had similarly abused vulnerable girls in the town of Rochdale, northwest England.